TL-20-24CC77 SYGNOMICS Report
01/09/2022
SOC Drugs
# 1. Target: GSR
Drugs
Model Evidence
6 regulons containing the target(s), GSR are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
2. Target: VEGFA
Drugs
Model Evidence
19 regulons containing the target(s), VEGFA are overactive in this patient.
Hallmarks Enrichment
HALLMARK_HYPOXIA HALLMARK_MTORC1_SIGNALING HALLMARK_TNFA_SIGNALING_VIA_NFKB
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
Drugs in GBM Trials
# 1. Target: ALDH2
Drugs
Model Evidence
2 regulons containing the target(s), ALDH2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
2. Target: FNTA,FNTB
Drugs
Model Evidence
13 regulons containing the target(s), FNTA,FNTB are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
FDA Approved Drugs
# 1. Target: PLA2G2A,PLA2G5
Drugs
Model Evidence
8 regulons containing the target(s), PLA2G2A,PLA2G5 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
2. Target: HBB
Drugs
Model Evidence
2 regulons containing the target(s), HBB are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
3. Target: VKORC1
Drugs
Model Evidence
2 regulons containing the target(s), VKORC1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
4. Target: CA2
Drugs
Model Evidence
15 regulons containing the target(s), CA2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
5. Target: ABL1
Drugs
Model Evidence
5 regulons containing the target(s), ABL1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
6. Target: OXTR
Drugs
Model Evidence
11 regulons containing the target(s), OXTR are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
7. Target: RTN4
Drugs
Model Evidence
3 regulons containing the target(s), RTN4 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
8. Target: LOXL2
Drugs
Model Evidence
1 regulons containing the target(s), LOXL2 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
9. Target: BSG
Drugs
Model Evidence
2 regulons containing the target(s), BSG are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
10. Target: NDUFA13
Drugs
Model Evidence
5 regulons containing the target(s), NDUFA13 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_DNA_REPAIR HALLMARK_MYC_TARGETS_V1
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
11. Target: TSG101
Drugs
Model Evidence
2 regulons containing the target(s), TSG101 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_DNA_REPAIR HALLMARK_MYC_TARGETS_V1
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
12. Target: RPS6KB1
Drugs
Model Evidence
1 regulons containing the target(s), RPS6KB1 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
13. Target: NQO1
Drugs
Model Evidence
2 regulons containing the target(s), NQO1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
14. Target: PLA2G2A
Drugs
Model Evidence
2 regulons containing the target(s), PLA2G2A are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
15. Target: TRPV4
Drugs
Model Evidence
1 regulons containing the target(s), TRPV4 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
16. Target: MAPK1,MAPK3
Drugs
Model Evidence
19 regulons containing the target(s), MAPK1,MAPK3 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
17. Target: ABAT
Drugs
Model Evidence
16 regulons containing the target(s), ABAT are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
18. Target: TNFRSF1A
Drugs
Model Evidence
15 regulons containing the target(s), TNFRSF1A are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
19. Target: EEF2
Drugs
Model Evidence
10 regulons containing the target(s), EEF2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
20. Target: HSPA8
Drugs
Model Evidence
27 regulons containing the target(s), HSPA8 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
21. Target: HRH1
Drugs
Model Evidence
43 regulons containing the target(s), HRH1 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_KRAS_SIGNALING_UP
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
22. Target: CA12,CA2,CA4
Drugs
Model Evidence
24 regulons containing the target(s), CA12,CA2,CA4 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
Network Plots
23. Target: CA2,CA4
Drugs
Model Evidence
15 regulons containing the target(s), CA2,CA4 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
24. Target: APP
Drugs
Model Evidence
36 regulons containing the target(s), APP are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
25. Target: SLC6A9
Drugs
Model Evidence
13 regulons containing the target(s), SLC6A9 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
26. Target: FNTA,FNTB
Drugs
Model Evidence
13 regulons containing the target(s), FNTA,FNTB are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
Network Plots
27. Target: HRH1,SLC6A2
Drugs
Model Evidence
43 regulons containing the target(s), HRH1,SLC6A2 are overactive in this patient.
Hallmarks Enrichment
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_KRAS_SIGNALING_UP
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
28. Target: GSR
Drugs
Model Evidence
6 regulons containing the target(s), GSR are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
29. Target: JAK2
Drugs
Model Evidence
17 regulons containing the target(s), JAK2 are overactive in this patient.
Hallmarks Enrichment
None
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
30. Target: SOD1
Drugs
Model Evidence
5 regulons containing the target(s), SOD1 are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
31. Target: ACVR2B
Drugs
Model Evidence
5 regulons containing the target(s), ACVR2B are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
No additional evidence was found
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
32. Target: VEGFA
Drugs
Model Evidence
19 regulons containing the target(s), VEGFA are overactive in this patient.
Hallmarks Enrichment
HALLMARK_HYPOXIA HALLMARK_MTORC1_SIGNALING HALLMARK_TNFA_SIGNALING_VIA_NFKB
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
33. Target: UGCG
Drugs
Model Evidence
41 regulons containing the target(s), UGCG are overactive in this patient.
Hallmarks Enrichment
Literature Evidence
Glioblastoma Clinical Trials
No glioblastoma clinical trials were found for these drugs.
Network Plots
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